From Joe Rogan praising BPC-157 on the world’s most-listened-to podcast to Jennifer Aniston’s weekly peptide injections to Kris Jenner calling them a “game changer” at 70, celebrities have turned peptides into one of 2026’s defining wellness obsessions, backed by a peptide therapeutics market valued at nearly $50 billion.
Who Are the Celebrities Using Peptides?
The list of public figures openly discussing peptide use has grown dramatically. Here’s who’s talking, what they’re using, and why it matters for the trend.
Joe Rogan: The BPC-157 Evangelist
No single person has done more to popularize peptides than Joe Rogan. The UFC commentator, comedian, and host of The Joe Rogan Experience, consistently the most-listened-to podcast on the planet, has discussed BPC-157 dozens of times across episodes, often with genuine enthusiasm about its healing effects.
Rogan’s most-told peptide story involves chronic elbow tendonitis that resisted conventional treatment. He told his audience he started using BPC-157 and it was gone in two weeks — for a problem that had persisted through physical therapy and rest.
In a 2025 episode with comedian Andrew Schulz, Rogan admitted he was essentially playing doctor, recommending BPC-157 to injured friends. When Schulz joked about it being secret “Wolverine shit” for healing, Rogan didn’t hesitate: “Yeah, get that. It’s legit. Super legit.”
Rogan’s go-to combination is BPC-157 paired with TB-500, a pairing practitioners call “the Wolverine stack.” During a recent episode featuring Matt Damon and Ben Affleck, Rogan advised both actors directly: “If you ever get injured, get immediately on BPC-157 and TB-500.”
After an Achilles injury sustained while elk hunting in Utah, Rogan revealed his full recovery protocol was simply “BPC-157 and TB-500, that’s it.” At 58, training Brazilian Jiu-Jitsu, kickboxing, and heavy lifting, Rogan’s advocacy carries enormous weight with his audience.
Jennifer Aniston: Weekly Injections and the Salmon Sperm Facial
Jennifer Aniston, 57, has been remarkably candid about her anti-aging regimen. In a Wall Street Journal Magazine cover story, the actress revealed she gets weekly anti-aging peptide injections.
In the same interview, Aniston disclosed one of Hollywood’s more unusual beauty treatments: a salmon sperm facial involving microneedling her skin with salmon sperm, which is rich in DNA fragments.
Aniston’s peptide connection runs deeper than personal use. She became Vital Proteins’ Chief Creative Officer back in 2020, and the collagen peptides brand, now owned by Nestlé, has ridden her endorsement to category dominance. The collagen peptides market was valued at approximately $771.8 million in 2025, projected to reach $1.27 billion by 2035.
Gwyneth Paltrow: The Goop Podcast Peptide Deep Dive
Gwyneth Paltrow has positioned herself at the intellectual center of the celebrity peptide conversation. On the Goop podcast, she sat down with Stanford neuroscientist Andrew Huberman to explore what she called “the emerging world of peptides.”
Paltrow told Huberman she was “a big fan of your work” and that her 19-year-old son quotes him constantly, a telling detail about how peptide curiosity has crossed generational lines.
Hailey Bieber: Peptides Go Mainstream Beauty
Hailey Bieber took a different route into the peptide world, through topical beauty products rather than injections. As founder of Rhode, now part of e.l.f. Beauty, Bieber was an early adopter, serving up her cult-favorite Peptide Lip Tint years before the rest of the industry joined in.
The Peptide Lip Tint sells for $20 and has become a permanent core lineup product. In October 2026, Rhode launched new shades at Sephora across Europe and the UK, then globally. Her approach — making peptides accessible through a $20 lip product rather than a $500 clinic visit — has normalized the category for the 18-to-30 demographic.
The Kardashian-Jenner Peptide Pipeline
Kris Jenner, 70, revealed she turned to peptides after a $100,000 facelift. She uses Omi’s Hair Growth Peptides and became a stakeholder in the brand. “I started taking [them] as a gummy form, two a day, and it pretty much changed my life,” Jenner said. During a May 2026 podcast appearance, Jenner revealed she tried Ozempic but it made her feel unwell. “I realized that a peptide injection was really great for me,” she said, calling it a “game changer.”
Khloé Kardashian has stated she “cannot see life without peptides.” Kim Kardashian, 45, revealed she takes “probably 35 supplements a day.” Google searches for “how many supplements to take a day” are up 66% in the last 12 months.
Chelsea Handler has been candid about pharmaceutical-grade GLP-1 medications. Country star LeAnn Rimes has focused on peptides and regenerative protocols following a chronic illness period.
Why Did Peptides Become a Celebrity Obsession?
The podcast effect. Rogan’s show reaches tens of millions of listeners per episode. When he calls something “legit. Super legit,” it moves markets.
The GLP-1 halo. The explosive success of semaglutide and tirzepatide, themselves peptides, legitimized the entire category. The global GLP-1 weight loss drug market is projected to exceed $100 billion by 2030, per Goldman Sachs. US patients grew from 6 million in 2023 to an estimated 20 million-plus in 2026.
The longevity economy. Peptides sit at the intersection of biohacking, longevity science, and concierge medicine, all booming among the wealthy.
Visual culture. The beauty industry’s embrace — peptide lip tints, peptide serums, peptide eye tapes — made the word “peptide” feel as normal as “retinol.”
By the Numbers: The Peptide Economy
- The peptide therapeutics market is valued at $49.68 billion in 2026, projected to reach $70.20 billion by 2031, per Mordor Intelligence.
- The GLP-1 weight loss drug market grew from $24 billion in 2023 to a projected $72 billion in 2026, with Goldman Sachs forecasting $100 billion by 2030.
- US patients on GLP-1 drugs rose from 6 million (2023) to an estimated 20 million-plus (2026).
- The average monthly cost of GLP-1 treatment fell from $1,200 (2023) to approximately $750 (2026).
- The FDA has approved over 110 peptide-based drugs globally as of 2024.
- “How many supplements to take a day” Google searches are up 66% in the last 12 months.
The Beauty Angle: Peptides in Your Medicine Cabinet
You don’t need a prescription or a syringe to participate in the peptide trend:
- Rhode Peptide Lip Tint ($20), Hailey Bieber’s hero product
- Biodance Collagen Peptide Jelly Serum Mist ($19 at Sephora)
- Drunk Elephant Kamo Triple-Peptide Cover Drops
- Lion Pose Pep Melt Cleansing Barrier Balm, from Mindy Kaling’s brand
- Peter Thomas Roth Peptide Skinjection Face and Eye Tape ($36)
For more on LA’s wellness scene, check out our guides to wellness hotels in Los Angeles and where to get peptide therapy in Los Angeles.
What Are the Risks? The Regulatory Reality
Most injectable peptides promoted by influencers have never been FDA-approved. The FDA has been escalating enforcement: 58 warning letters in September 2025, criminal prosecutions in December 2025, 30 telehealth companies warned in February 2026, and more vendor warnings in August 2026.
“These influencers are often advocating taking a stack of peptides each month, so it could be two, three, four different peptides. This is really what I consider dangerous.” — Dr. Eric Topol, Scripps Research
For a deeper look at what doctors want you to know about peptide safety, see what doctors want you to know about peptide safety on TopDoctor Magazine. For what the research actually shows, see what the research actually shows. And for the biohacking community’s take on peptides, visit The Biohack.
What’s Next for the Peptide Trend?
Regulatory clarity (or crackdown). The FDA’s 2026 enforcement actions suggest the gray market’s days are numbered.
The next generation. Retatrutide posted 28.3% weight loss in trials. Oral GLP-1 pills are arriving.
Celebrity saturation point. As more stars disclose use, peptides become simply another wellness category. The question is whether the science catches up to the marketing.
Frequently Asked Questions
Which celebrities use peptides?
Joe Rogan (BPC-157, TB-500), Jennifer Aniston (weekly peptide injections), Gwyneth Paltrow (peptide discussions on Goop), Hailey Bieber (topical peptide beauty products), Kris Jenner (peptide injections and hair peptides), Khloé Kardashian, Chelsea Handler (GLP-1s), and LeAnn Rimes have all discussed peptide use publicly.
What peptides does Joe Rogan take?
Rogan’s stated protocol is BPC-157 and TB-500. He uses them primarily for injury recovery.
Are celebrity peptide endorsements trustworthy?
Celebrity anecdotes are not clinical evidence. Many celebrities have financial relationships with wellness brands. Always consult a physician.
Is the peptide trend legal?
FDA-approved peptides prescribed by doctors are legal. Most “research peptides” sold online for human use are technically illegal.
This article is for entertainment and informational purposes. It is not medical advice. Consult a licensed physician before making any health decisions.
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